PP1B (AF9B12) Monoclonal Antibody

Size
0.1ml
Catalog no.
bsm-50383M
Price
362 EUR
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Tested Applications

WB

Gene ID number

5500

Target Antigen

PP1B

Modification(s)

None

Clone number

AF9B12

Swiss Prot

P62140

French translation

anticorps

Clonality

Monoclonal

Concentration

1ug per 1ul

Conjugation

Unconjugated

Recommended dilutions

WB (0.2 ug/ml)

Cross reactivity

Human, Mouse, Rat

Category

Primary Antibodies

Modification site(s)

Unmodified antibody

Purification method

Purified by Protein G.

Long name

PP1B (AF9B12) Monoclonal Antibody

Also known as

PP1B (AF9B12) Monoclonal Antibody

Specificity

This is a highly specific antibody against PP1B.

Source

Recombinant human protein purified from E.coli (His-PP1B)

Cross reactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

Synonym names

PP1B; PP-1B; PPP1CD; PP1beta; HEL-S-80p; Serine/threonine-protein phosphatase PP1-beta catalytic subunit; PPP1CB

Storage conditions

Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.

Properties

If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

About

Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.

Background of the target antigen

Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).