PPP1CB Polyclonal Antibody

Size
100 μg
Catalog no.
CAC08014
Price
401 EUR
Buy

Verified reactivity

Human

Raised in

Rabbit

Use before

1 year

Protein number

P62140

Shipping requirements

Blue ice

French translation

anticorps

Clonality

Polyclonal

Estimated production time

3-7 business days

NCBI number

Please refer to NCBI

Gene number

Please refer to GenBank

Purity

Protein G purified,>95%

Group

Polyclonals and antibodies

Notes

For research use only. Not for diagnostic procedures.

Storage recommendation

Aliquot and store at -20°C. Minimize freezing and thawing.

Verified applications

ELISA,WB,IHC. Recommended dilution:WB:1:500-1:5000,IHC:1:20-1:200

Other name

Serine/threonine-protein phosphatase PP1-beta catalytic subunit,PP-1B,PPP1CD,PPP1CB

Immunogen

Recombinant Human Serine/threonine-protein phosphatase PP1-beta catalytic subunit protein (2-327AA)

Properties

If you buy Antibodies supplied by bioma they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

About

Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.

Supplementary information

Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).